RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
CCN4
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
qRT-PCR; Immunohistochemistry; etc.
Target
NA
Pathway
NA
PubMed ID
Title
WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis
Year
2009
Function
"WISP1 enhanced fibrogenesis by inducing EMT of ATII cells and increasing collagen production by fibroblasts, indicating that WISP1 exerts its profibrotic effects by a multitude of autocrine and paracrine effects in the lung."